Rajinikanth

Dr. Vaseegaran / Chitti

Aishwarya Rai Bachchan

Sana

Danny Denzongpa

Dr. Bohra

Santhanam

Siva

Karunas

Ravi

Devadarshini

Latha

Sabu Cyril

Agent Shah

Kalabhavan Mani

Pachaimuthu

Cochin Haneefa

Traffic Police

Raaghav

Neighbourhood Bully

Boxer Dheena

Thug

Shriya Sharma

Curious Student

Sugunthan

Police Inspector

Delhi Kumar

Vaseegaran's Father

Revathi Sankaran

Vaseegaran's mother

Chaams

Barber

Devadasu Kanakala

K. Bhajanlal, a customer at The Park Hotel

Rekha Suresh

Savitha Reddy

Sana (voice)